Week 1: Odds, lines and totals for every game

The 2026 season kicked off Wednesday with the Seattle Seahawks taking down the New England Patriots 13-10 in a Super Bowl rematch, followed by a somewhat surprisingly easy win for the San Francisco 49ers over the Los Angeles Rams on Thursday in Australia.

The action continues with a 13-game Sunday slate, with the Buffalo Bills-Houston Texans matchup highlighting the early afternoon games. The Bills come in as slight favorites. The Sunday night game features a classic NFC East rivalry, as the Dallas Cowboys visit the New York Giants as 3-point road favorites.

A whopping 12 Week 1 games have spreads of 3.5 points or less. The Los Angeles Chargers are the biggest favorite of the week, laying 9.5 points to the Arizona Cardinals.

The week wraps up with Patrick Mahomes making his comeback from a torn ACL when the Kansas City Chiefs (-2.5, 43.5) host the Denver Broncos on "Monday Night Football" (8:15 ET on ABC/ESPN).

Here's a look at the odds for every Week 1 game.

Note: Odds by DraftKings and subject to change.

Jump to:
NE-SEA | SF-LAR | TB-CIN | NO-DET
NYJ-TEN | BAL-IND | ATL-PIT | CHI-CAR
CLE-JAX | BUF-HOU | MIA-LV | GB-MIN
WSH-PHI | ARI-LAC | DAL-NYG | DEN-KC

Sunday

Tampa Bay Buccaneers at Cincinnati Bengals (-3.5)
1 p.m. ET on Fox, Paycor Stadium, Cincinnati

Moneyline: Bengals -198, Buccaneers +164
Total: 50.5 points
FPI favorite: Bengals by 3.2, 62.4% to win outright

New Orleans Saints at Detroit Lions (-7)
1 p.m. ET on Fox, Ford Field, Detroit

Moneyline: Lions -310, Saints +250
Total: 49.5 points
FPI favorite: Lions by 6.8, 73.6% to win outright

Check out each team's futures odds here. For the latest, visit DraftKings.

New York Jets at Tennessee Titans (-1.5)
1 p.m. ET on CBS, Nissan Stadium, Nashville, Tenn.

Moneyline: Titans -125, Jets +105
Total: 38.5 points
FPI favorite: Titans by 2.4, 58.0% to win outright

Baltimore Ravens (-3.5) at Indianapolis Colts
1 p.m. ET on CBS, Lucas Oil Stadium, Indianapolis

Moneyline: Ravens -175, Colts +145
Total: 47.5 points
FPI favorite: Ravens by 2.5, 59.5% to win outright

Atlanta Falcons at Pittsburgh Steelers (-5.5)
1 p.m. ET on Fox, Acrisure Stadium, Pittsburgh

Moneyline: Steelers -230, Falcons +190
Total: 41.5 points
FPI favorite: Steelers by 2.4, 58.0% to win outright

Chicago Bears (-3) at Carolina Panthers
1 p.m. ET on Fox, Bank of America Stadium, Charlotte, N.C.

Moneyline: Bears -170, Panthers +142
Total: 47.5 points
FPI favorite: Bears by 2.7, 58.2% to win outright

Cleveland Browns at Jacksonville Jaguars (-8.5)
1 p.m. ET on CBS, EverBank Stadium, Jacksonville, Fla.

Moneyline: Jaguars -455, Browns +350
Total: 39.5 points
FPI favorite: Jaguars by 7.9, 76.6% to win outright

Buffalo Bills (-1.5) at Houston Texans
1 p.m. ET on CBS, NRG Stadium, Houston

Moneyline: Bills -118, Texans -102
Total: 44.5 points
FPI favorite: Bills by 1.0, 53.7% to win outright

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Miami Dolphins at Las Vegas Raiders (-3)
4:25 p.m. ET on Fox, Allegiant Stadium, Las Vegas

Moneyline: Raiders -170, Dolphins +142
Total: 40.5 points
FPI favorite: Raiders by 3.0, 61.4% to win outright

Green Bay Packers at Minnesota Vikings (-1.5)
4:25 p.m. ET on CBS, U.S. Bank Stadium, Minneapolis

Moneyline: Vikings -122, Packers +102
Total: 46.5 points
FPI favorite: Packers by 1.8, 56.6% to win outright

Washington Commanders at Philadelphia Eagles (-6)
4:25 p.m. ET on Fox, Lincoln Financial Field, Philadelphia

Moneyline: Eagles -250, Commanders +205
Total: 44.5 points
FPI favorite: Eagles by 4.8, 66.3% to win outright

Arizona Cardinals at Los Angeles Chargers (-9.5)
4:25 p.m. ET on CBS, SoFi Stadium, Inglewood, Calif.

Moneyline: Chargers -500, Cardinals +380
Total: 47.5 points
FPI favorite: Chargers by 9.6, 80.2% to win outright

Dallas Cowboys (-3) at New York Giants
8:20 p.m. ET on NBC, MetLife Stadium, East Rutherford, N.J.

Moneyline: Cowboys -162, Giants +136
Total: 48.5 points
FPI favorite: Cowboys by 2.2, 58.3% to win outright

Monday

Denver Broncos at Kansas City Chiefs (-2.5)
8:15 p.m. ET on ESPN/ABC, GEHA Field at Arrowhead Stadium, Kansas City, Mo.

Moneyline: Chiefs -148, Broncos +124
Total: 43.5 points
FPI favorite: Chiefs by 2.5, 57.8% to win outright

Thursday's result

San Francisco 49ers vs. Los Angeles Rams (-3.5)
Melbourne Cricket Ground, Melbourne, Australia

49ers 27, Rams 7

Moneyline: Rams -198, 49ers +164
Total: 48.5 points
FPI favorite: Rams by 2.9, 60.3% to win outright

Wednesday's result

New England Patriots at Seattle Seahawks (-3.5)
Lumen Field, Seattle

Seahawks 13, Patriots 10

Moneyline: Seahawks -180, Patriots +150
Total: 45.5 points
FPI favorite: Seahawks by 3.4, 61.1% to win outright